Paul Chazot (Durham, UK) and Ilona Obara (Newcastle upon Tyne, UK)
It is my pleasure to announce the last activity organised by the EHRS this year, which is a Festive Virtual Poster Event focused on Neuronal Histamine to be held on Thursday 16 December 2021 at 12.00 noon CET (expected duration: 1h 30min). Please save the date!
The Webinar is organized by Drs Paul Chazot (Durham, UK) and Ilona Obara (Newcastle upon Tyne, UK). See attached abstracts, programme and details on how to join. Note that you will have the chance to look at the posters ‐that will be uploaded in pdf format on the EHRS website‐ before the webinar and, as with the previous online activities, to interact and to share scientific progress and new ideas during the webinar.
We look forward to seeing you soon ʹvirtuallyʹ!
Best regards
on behalf of the EHRS
Katerina Tiligada EHRS President
Ilona Obara, Newcastle University, Newcastle upon Tyne, UK Astrid Sasse, Trinity College Dublin, Dublin, Ireland
The planning of the 49th Annual Meeting of the European Histamine Research Society (EHRS) to be held in the ‘Wolfsburg’ in Düsseldorf/Mühlheim an der Ruhr (Germany) was well under way, when we were all met with the challenge of adapting our lives to the new measures set by the Covid‐19 pandemic. There are many challenges we are facing everyday, however, keeping the good spirit of histamine lovers is not one of them. Together with EHRS Council, we would like to express our most sincere welcoming greetings to you for the Online Symposium of the 49th Annual EHRS Meeting.
Within the Symposium, there are two 2 h sessions held on the 1st and 2nd July 2020. We have selected Blackboard Collaborate as a platform to hold the Online Symposium. The link and details on how to join the Symposium are stated within the program of each session. In order to help things run smoothly, the same link will work for both sessions. The sessions will begin at 13:00 CEST1, however you will be able to join the Symposium 30 minutes prior to commencement.
The Symposium will cover a range of interesting topics around the molecular and clinical pharmacology of histamine. All presenters are sincerely welcome, as well as all other participants who are interested in these topics. We invited young members of our Society to share with us their research findings in oral presentations. The Bursary Award Committee will select the best and most enthusiastic young presenter who will receive a Bursary Award towards next years’ 50th Annual EHRS Meeting in Hannover, Germany. We hope everyone will be in high spirits, supporting and encouraging our young members during their presentations whilst also challenging them with questions during the discussion.
We hope this will be a memorable and successful Symposium due to the wonderful science and our drive to keep learning about histamine and not due to the current unprecedented circumstances.
Sincerely,
The Organizing Committee
Ilona Obara, Newcastle University, Newcastle upon Tyne, UK Astrid Sasse, Trinity College Dublin, Dublin, Ireland
Professor Kiec-Kononowicz
Astrid Sasse
Emanuela Masini and Beatrice Passani
Francisca Maria (Kika) Sanchez Jimenez
Jian-Sheng Lin
Prof Jean-Charles SCHWARTZ, Bioprojet , Paris
«Clinical trials with Pitolisant, a wake-promoting H3-receptor inverse agonist »
Prof Olga A. SERGEEVA, Heine-Univ. Dusseldorf
« Histamine—dopamine interactions in health and disease »
Prof Kazuhiko YANAI, Tohoku Univ., Sendai
« Neuroimaging studies in humans on the histaminergic neuron system: past, present and future »
Prof Yrjo KONTTINEN , Biomedicum Helsinki
« Non-professional histamine producing cells and H4R in immune reactions in general and in the pathogenesis of Sjögren’s syndrome in particular»
Dr Antoine ADAMANTIDIS, McGill University Montréal
« The MCH Histamine connection: a possible modulatory circuit for REM sleep ?»
Professor Jean-Charles Schwartz
Agnieszka Fogel
Histamine synthesis and its functions in murine mast cells
Satoshi Tanaka (Jap)
Histamine and addiction: From behavior to neurotransmitter interactions
Pertti Panula (Fin)
Histamine at the intersection of circadian rhythms and the sleep-wake cycle
William Wisden (UK)
Toward selective molecular tools for histamine H2 and H4 receptors: Conformational constraints, bioisosteric and bivalent approaches
Armin Buschauer (Ger)
Histamine signaling in pathomechanisms of inflammatory bowel disease (IBD)
Marek Jutel (Pol)
Wieslawa Agnieszka Fogel (oration by Wilfried Lorenz)
Madeleine Ennis
COST Action BM0806 ‘Recent advances in histamine receptor H4R research’
Interactions between mast cells and structural airway cells in the pathogenesis of asthma
Peter Bradding (UK)
Histamine H4 receptor – ligand, binding and activation
Holger Stark (Germany)
H4R and neuroinflammation: insights from mouse experimental autoimmune encephalomyelitis
Beatrice Passani (Italy)
Late signaling events for histamine release by mast cells
Ulrich Blank ( France)
Eicosanoids – performing lipidiomics on activated mast cells
Gunnar P. Nilsson (Sweden)
The allergic effector unit: mast cells – eosinophils interactions regulate the allergic response
Francesca Levi-Schaffer (Israel)
What’s new in H4 research?
Moderated by:
Rob Thurmond (USA)
Elena Rivera (Argentina)
Paul Chazot (UK)
Ralph Gutzmer (Germany)
Holger Stark (Germany)
Zsuzsanna Huszti (oration by Anita Sydbom)
Helmut L Haas (oration by Patrizio Blandina)
Roman Khanferyan
The role of the Histamine H4 receptor in allergy and inflammation
Robin.L. Thurmond (USA)
Viruses and Asthma
Nikos Papadopoulos (Greece)
H1/H2 Receptor in Allergic and Immune Response
Marek Jutel (Poland)
Is brain Histamine involved in depression?
Patrizio Blandina (Italy)
EHRS – Birth of the Histamine Club
Wilfried Lorenz (Germany)
40 years EHRS – good science, fun and friends in Europe? Madeleine Ennis (Northern Ireland)
Paul Chazot
Clinical applications of pitolisant (BF2.649), an inverse agonist at the H3 receptor.
Jean-Charles Schwartz (France)
Functional implications of Histaminergic Neurons Heterogeneity
Patrizio Blandina (Italy)
Translational approaches towards the identification of a histamine H3 receptor antagonist and its’ clinical evaluation for the symptomatic treatment of allergic rhinitis
Nick Carruthers (USA)
Discovery of Novel Agents for the Treatment of CNS Disorders
Jorge Brioni (USA) (given by M. Cowart)
Histamine H3 antagonist properties and efficacy in CNS models
Marlon Cowart (USA)
Histamine H3 and H4 receptors – therapeutic opportunities in airway and inflammatory diseases
Steve Liu (UK)
Histamine as a neurotransmitter in brain: from discovery to novel psychotropic drugs – A short history dedicated to the memory of Sir James Black (1924-2010)
Jean-Charles Schwartz (France)
Medicinal Chemistry & Receptor Modelling
Rob Leurs
Genomics & Bioinformatics
Andràs Falus
n vivo preclinical studies
Abdel Ennaceur
Antibody production & validation
Paul Chazot
Inflammation models
Emanuela Masini
COST Action BM0806 ‘Recent advances in histamine receptor H4R research’
Friedhelm Diel
Flexibilities within and around hematopoietic cell development
Fritz Melchers (Ger)
Roles of transcription factor STAT3 in cancer and immune disorders
Karlheinz Friedrich (Ger)
Histamine-dependent and – independent itch and pain
Martin Schmelz (Ger)
Histamine and pregnancy
Erna Pap (Hun)
Basophils – clinical aspects
Jörg Kleine-Tebbe (Ger)
The clinical usefulness of basophil histamine release
Per S Skov (Den)
New molecular insights in the H4R – receptor field
Rob Leurs (Ne)
H4R-ligands – clinical aspects
Robin Thurmond (USA)
Nina Grosman Memorial Lecture
Histamine and the “omics” era
Andras Falus (Hun)
Wolfgang Schmutzler Memorial Lecture
Basophils – basic science aspects
Bernhard Gibbs (UK)
Madeleine Ennis (oration by Fred Pearce)
Fred Pearce (oration by Madeleine Ennis)
Bruno Mondovi (oration by Pierfrancesco Mannaioni)
Sven-Erik Dahlén and Anita Sydbom
Mast cells, nerves and IgE
John Bienenstock (Canada)
Post-consolidation therapy with histamine dihydrochloride and interleukin-2 in acute myelogenous leukemia.
Kristoffer Hellstrand (Sweden)
The vertebrate brain histaminergic system: a multifaceted network.
Pertti Panula (Finland)
Differential release of mast cell mediators – implications in health and disease.
Gunnar Nilsson (Sweden)
The role of serglycin proteoglycan in mast cell secretory granule formation
Gunnar Pejler (Sweden)
Intracellular trafficking and signaling mechanisms in the secretion of inflammatory mediators and histamine by mast cells.
Ulrich Blank (France)
Emanuela Masini
And then there were four…
Rob Leurs (Netherlands)
Oxidative stress and monoamineoxidases: from basic studies to novel therapeutical interventions.
Angelo Parini (France)
Anaphylaxis: pathophysiology and management.
Johannes Ring (Germany)
Robin Ganellin (oration by Sir James Black)
Walter Schunack (oration by Holger Stark)
Henk Timmerman (oration by Rob Leurs)
Catherine Tiligada
Histamine and systems biology; genes and genomics beyond genes
Andras Falus (Hungary)
Histamine and the EHRS – what has happened in the last 35 years?
Madeleine Ennis (UK)
Occupational asthma: diagnosis and management
Piero Maestrelli (Italy)
Mrs Ingrid Olhagen-Uvnäs (oration by Anita Sydbom)
Lovro Stanovnik
My journey with histamine from the cardiovascular system to the brain
Marija Carman-Krzan (Slovenia)
Superallergens: a new mechanism of immunologic activation of human basophils and mast cells
Gianni Marone (Italy)
The role of mast cells in allergic disease and innate immunity
Michael A. Beaven (USA)
Wilfried Lorenz (oration by Madeleine Ennis)
Piero Mannaioni (oration by Emanuela Masini)
Takehiko Watanabe (oration by Kazuhiko Yanai)
Helmut Haas
The riddle of the mast cell receptors in the immune response
P. Mannaioni (Firenze, Italy)
Histamine and orexin neurons: synergistic and complementary regulation of the sleep-wake cycle?
Jiang-Sheng Lin (Lyon, France)
Histamine receptors and susceptibility to central nervous system autoimmune disease
C. Teuscher (Burlington, Vermont, USA)
How to bind and activate histamine H1 receptors
R. Leurs (Amsterdam, The Netherlands)
Henk Timmerman and Rob Leurs
The role of chronic inflammation and remodelling in the pathogenesis of persistent asthma
S.T. Holgate (UK)
Histamine and histamine receptors in CNS disorders
P. Panula (Finland)
Histamine H1- and H3-receptor subtypes: Targets for drug development
W. Schunack (Germany)
Pain perception and the histaminergic system
L.B. Hough (USA)
Wolfgang Schmutzler (oration by Fred Pearce)
Andras Falus
Getting away from histamine
GR Gannellin (UK)
The histamine – cytokine connection
Michel Dy (France)
Histamine uptake by non-neuronal cells of the brain: properties and function
Zsuzsanna Huszti (Hungary)
Pertti Panula
Histamine’s Wake
Helmut Haas (Düsseldorf)
Roles of H1R and H2R in immune and gastric function. Study by histamine receptor-deficient mice
Takeshi Watanabe (Fukuoka)
Histamine receptors, a versatile subject for studying molecular aspects of receptors and receptor mechanisms
Professor Henk Timmerman (Amsterdam)
Bruno Mondovi
Paradigms in histamine research: many controversies – many solutions
W. Lorenz (Marburg)
Histidine decarboxylase: from purification to gene knockout
T. Watanabe (Tohoku University)
Structure and function of copper-containing amine oxidases
L. Morpurgo
Autacoids modulation of ischaemia-reperfusion injury
E. Masini (Florence)
Franc Erjavec (oration by Maria Carmen-Krzan)
Jack Peter Green (oration by Patrizio Blandina)
Philippe Belon
Clinical significance of mast cell heterogeneity
Madeleine Ennis (UK)
Modulation of allergen and anti-IgE induced human basophil activation by serial histamine dilutions
Jean Sainte-Laudy (Paris, France)
Agnieszka Fogel
Mast cell heterogeneity
Fred Pearce (London)
Adventures with histamine
Sir James Black (London)
Brain histamine and the H3 receptor from function to therapy
Jean-Charles Schwartz (Paris)
Sir James Black (oration by Robin Ganellin)
Czeslaw Maslinski (oration by Walter Schunack)
Jean West (oration by Fred Pearce)
Histamine and antihistamine drugs in septic shock
Eddy Neugebauer
Frans J. van Overveld
The role of allergy in asthma – Implications for proper asthma management
M.A. Kaliner (USA)
Milestones in histamine research
Börje Uvnas (Sweden)
Release mechanisms of dense core secretory granules in peritoneal mast cells
G. Alvarez de Toledo (Spain)
Igor S. Gushchin
Design of H3-receptor agonists and antagonists
Walter Schunack (Germany)
Zsuzsanna Huszti
Histaminergic neuron system in brain: recent advances
T. Watanabe (Japan)
Eddy Neugebauer
Histamine, the heart of the matter
Roberto Levi (USA)
Manuel García-Caballero
Highly potent and selective ligands for histamine receptor subtypes
W. Schunack (Germany)
Intracellular histamine receptors – The new frontier
L.J. Brandes (Canada)
W. Lorenz
The impact of histamine research on clinical anesthesia and surgey
J. Moss (USA)
Geoff West
Börje Uvnäs
Histamine, a stimulant to physiological imagination
James Black (UK)
J.J. Keyzer
Histamine, state of the art
W. Lorenz (Germany)
Histamine as a neurotansmitter in the brain
Schwartz (Germany)
Histamine in asthma
T.S. Holgate (UK)
Mechanisms of histamine secretion
N. Chakravarthy
S. Norn
Our unique society
G.B. West (England)
New aspects in asthma pathogenesis and development of anti-allergic drugs
A.M. Edwards (England)
Mast cells, neuropeptides and inflammation
M.K. Church (England)
Interaction between inositol phosphates and Ca2+ in signal transduction mechanisms
O. Thastrup (Denmark)
L. Benes / R. Nosal
The release of histamine by free radicals
P.F. Mannaioni (Italy)
Nirmal Chakravarty
Mechanisms of signal transduction in mast cells and basophils: Studies with RBL-2H3 cells
Mike Beaven (Bethesda, USA)
Pier Francesco Mannaioni
Turnover of histamine in rat brain
J. Green (USA)
GB West
Antisecretagogues and parietal cells
Karl Sewing (Hannover)
Franc Erjavec
Histamine release and vascular changes induced by neuropeptides
John Foreman (London)
Karl F Sewing
Histamine secretion: research in retrospect
Bertil Diamant (Copenhagen)
Zsuzsanna Huszti
The multiple facets of histamine research
HO Schild
Mechanisms of regulation of the biogenic amine levels in tissues with a special reference to histamine
Czeslaw Maslinski