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These are some of the most recent exciting publications in the field of Histamine research

Ekaterini Tiligada, Madeleine Ennis
Histamine pharmacology: from Sir Henry Dale to the 21st century
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Abdurakhmanova S, Chary K, Kettunen M, Sierra A, Panula P.
Behavioral and stereological characterization of Hdc KO mice: relation to Tourette syndrome.
J Comp Neurol. 2017 Jul 6. doi: 10.1002/cne.24279. [Epub ahead of print]
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Szakacs Z1, Dauvilliers Y2, Mikhaylov V3, Poverennova I4, Krylov S5, Jankovic S6, Sonka K7, Lehert P8, Lecomte I9, Lecomte JM9, Schwartz JC10; HARMONY-CTP study group.
Safety and efficacy of pitolisant on cataplexy in patients with narcolepsy: a randomised, double-blind, placebo-controlled trial.
Lancet Neurol. 2017 Mar;16(3):200-207.
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Schneider EH, Seifert R.
Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutantsin the Sf9 Cell Expression System.
Handb Exp Pharmacol. 2017 Feb 24. doi: 10.1007/164_2016_124
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Shan L, Bao AM,Swaab DF.
Changes in Histidine Decarboxylase, Histamine N-Methyltransferase and Histamine Receptors in Neuropsychiatric Disorders.
Handb Exp Pharmacol. 2017 Feb 24. doi: 10.1007/164_2016_125.
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Pittenger C.
Histidine Decarboxylase Knockout Mice as a Model of the Pathophysiology of Tourette Syndrome and Related Conditions.
Handb Exp Pharmacol. 2017 Feb 24. doi: 10.1007/164_2016_127.
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Gabelle A, Jaussent I, Hirtz C, Vialaret J, Navucet S, Grasselli C, Robert P, Lehmann S, Dauvilliers Y.
Cerebrospinal fluid levels of orexin-A and histamine, and sleep profile within the Alzheimer process.
Neurobiol Aging. 2017 Jan 18;53:59-66.
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Chen J, Hong T, Ding S, Deng L, Abudupataer M, Zhang W, Tong M, Jia J, Gong H, Zou Y, Wang TC, Ge J, Yang X.
Aggravated myocardial infarction-induced cardiac remodeling and heart failure in histamine-deficient mice.
Sci Rep. 2017 Mar 8;7:44007. doi: 10.1038/srep44007.
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Schwartzbach CJ, Grove RA, Brown R, Tompson D, Then Bergh F, Arnold DL.
Lesion remyelinating activity of GSK239512 versus placebo in patients with relapsing-remitting multiple sclerosis: a randomised, single-blind, phase II study.
J Neurol. 2016 Nov 25. [Epub ahead of print]
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Hagenow S, Stasiak A, Ramsay RR, Stark H.
Ciproxifan, a histamine H3 receptor antagonist, reversibly inhibits monoamine oxidase A and B.
Sci Rep. 2017 Jan 13;7:40541
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Smolinska S, Groeger D, Perez NR, Schiavi E, Ferstl R, Frei R, Konieczna P, Akdis CA, Jutel M, OʼMahony L.
Histamine Receptor 2 is Required to Suppress Innate Immune Responses to Bacterial Ligands in Patients with Inflammatory Bowel Disease.
Inflamm Bowel Dis. 2016 Jul;22(7):1575-86.
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Barcik W, Pugin B, Westermann P, Perez NR, Ferstl R, Wawrzyniak M, Smolinska S, Jutel M, Hessel EM, Michalovich D, Akdis CA, Frei R, O'Mahony L.
Histamine-secreting microbes are increased in the gut of adult asthma patients.
J Allergy Clin Immunol. 2016 Nov;138(5):1491-1494.
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Alonso N, Zappia CD, Cabrera M, Davio CA, Shayo C, Monczor F, Fernández NC.
Physiological implications of biased signaling at histamine H2 receptors
Front Pharmacol. 2015 Mar 10;6:45.
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Zappia CD Granja-Galeano G, Fernández N, Shayo C, Davio C, Fitzsimons CP, Monczor F.
Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways.
Sci Rep. 2015 Dec 4;5:17476.
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Monczor F, Fernandez N.
Current Knowledge and Perspectives on Histamine H1 and H2 Receptor Pharmacology: Functional Selectivity, Receptor Crosstalk, and Repositioning of Classic Histaminergic Ligands.
Mol Pharmacol. 2016 Nov;90(5):640-648.
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Schwartzbach C, Grove RA, Brown R, Tompson D, Then Bergh F, Arnold DL.
Lesion remyelinating activity of GSK239512 versus placebo in patients with relapsing-remitting multiple sclerosis: a randomised, single-blind, phase II study.
J Neurol. 2016 Nov 25. [Epub ahead of print]
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Khanfar MA, Affini A, Lutsenko K, Nikolic K, Butini S, Stark H.
Multiple Targeting Approaches on Histamine H3 Receptor Antagonists
Front Neurosci. 2016 May 30;10:201
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Riddy DM, Cook A, Diepenhorst NA, Bosnyak S, Brady R, Mannoury-la-Cour C, Mocaer E, Summers RJ, Charman W, Sexton PM, Christopoulos A, Langmead CJ.
Isoform-specific biased agonism of histamine H3 receptor agonists.
Mol Pharmacol. 2016 Nov 18. pii: mol.116.106153. [Epub ahead of print]
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Kim YS, Kim YB, Kim WB, Yoon BE, Shen FY, Lee SW, Soong TW, Han HC, Colwell CS, Lee CJ, Kim YI.
Histamine resets the circadian clock in the suprachiasmatic nucleus through the H1R-CaV 1.3-RyR pathway in the mouse.
Eur J Neurosci. 2015 Oct;42(7):2467-7
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Uygun DS, Ye Z, Zecharia AY, Harding EC, Yu X, Yustos R, Vyssotski AL, Brickley SG, Franks NP, Wisden W.
Bottom-Up versus Top-Down Induction of Sleep by Zolpidem Acting on Histaminergic and Neocortex Neurons.
J Neurosci. 2016 Nov 2;36(44):11171-11184.
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Benetti F, Furini CR, de Carvalho Myskiw J, Provensi G, Passani MB, Baldi E, Bucherelli C, Munari L, Izquierdo I, Blandina P.
Histamine in the basolateral amygdala promotes inhibitory avoidance learning independently of hippocampus.
Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2536-42.
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Fabbri R, Furini CR Passani MB, Provensi G, Baldi E, Bucherelli C, Izquierdo I, de Carvalho Myskiw J, Blandina P.
Memory retrieval of inhibitory avoidance requires histamine H1 receptor activation in the hippocampus.
Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2714-20
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Schneider EH1, Neumann D2, Seifert R2.
Modulation of behavior by the histaminergic system: lessons from H(1)R-and H(2)R-deficient mice.
Neurosci Biobehav Rev. 2014 May;42:252-66.
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Schneider EH, Neumann D, Seifert R.
Modulation of behavior by the histaminergic system: lessons from HDC-, H3R- and H4R-deficient mice.
Neurosci Biobehav Rev. 2014 Nov;47:101-21
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Provensi G, Blandina P, Passani MB.
The histaminergic system as a target for the prevention of obesity and metabolic syndrome.
Neuropharmacology. 2016 Jul;106:3-12
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Kubo M, Kishi T, Matsunaga S, Iwata N.
Histamine H3 Receptor Antagonists for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.
J Alzheimers Dis. 2015;48(3):667-71.
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Thurmond RL, Greenspan A, Radziszewski W, Xu XL, Miao Y, Chen B2, Ge T, Zhou B, Baker D, Pavlova D, Ritchlin CT, Tanaka Y, Takeuchi T, Smolen JS.
Toreforant, A Histamine H4 Receptor Antagonist, in Patients with Active Rheumatoid Arthritis Despite Methotrexate Therapy: Results of 2 Phase II Studies.
J Rheumatol. 2016 Sep;43(9):1637-42.
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Levoin N, Labeeuw O, Billot X, Calmels T, Danvy D, Krief S, Berrebi-Bertrand I, Lecomte JM, Schwartz JC, Capet M.
Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening.
Eur J Med Chem. 2016 Sep 24;125:565-572
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Nieto-Alamilla G, Márquez-Gómez R, García-Gálvez AM, Morales-Figueroa G, Arias-Montaño JA
The Histamine H3 Receptor: Structure, Pharmacology, and Function.
Mol Pharmacol. 2016 Nov;90(5):649-673
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Mommert S, Ratz L, Herwig K, Rost M, Gutzmer R, Werfel T.
Genetic variations within the promotor region of the human histamine H4 receptor gene in psoriasis patients.
Pharmacol Res. 2016 Oct 7;114:121-127.
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Panula P, Chazot PL, Cowart M, Gutzmer R, Leurs R, Liu WL, Stark H, Thurmond RL, Haas HL.
International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.
Pharmacol Rev. 2015 Jul;67(3):601-55
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Kooistra A, Kuhne S, de Esch IJ, Leurs R, de Graaf C.
A structural chemogenomics analysis of aminergic GPCRs: lessons for histamine receptor ligand design.
Br J Pharmacol. 2013 Sep;170(1):101-26
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Birnkammer T, Spickenreither A, Brunskole I, Lopuch M, Kagermeier N, Bernhardt G, Dove S, Seifert R, Elz S, Buschauer A
The bivalent ligand approach leads to highly potent and selective acylguanidine-type histamine H2 receptor agonists.
J Med Chem. 2012 Feb 9;55(3):1147-60
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Tatsuro Shimamura, Mitsunori Shiroishi, Simone Weyand, Hirokazu Tsujimoto, Graeme Winter, Vsevolod Katritch, Ruben Abagyan, Vadim Cherezov, Wei Liu, Gye Won Han, Takuya Kobayashi, Raymond C. Stevens & So Iwata
Structure of the human histamine H1 receptor complex with doxepin
Nature 475,65-70 (07 July 2011)
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Beaven MA.
Our perception of the mast cell from Paul Ehrlich to now.
Eur J Immunol. 2009 Jan 7;39(1):11-25.
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Cowart MD, Altenbach RJ, Liu H, Hsieh GC, Drizin I, Milicic I, Miller TR, Witte DG, Wishart N, Fix-Stenzel SR, McPherson MJ, Adair RM, Wetter JM, Bettencourt BM, Marsh KC, Sullivan JP, Honore P, Esbenshade TA, Brioni JD.
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.
J Med Chem. 2008 Oct 23;51(20):6547-57. Epub 2008 Sep 26.
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van Rijn RM, van Marle A, Chazot PL, Langemeijer E, Qin Y, Shenton FC, Lim HD, Zuiderveld OP, Sansuk K, Dy M, Smit MJ, Tensen CP, Bakker RA, Leurs R.
Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor.
Biochem J. 2008 Aug 15;414(1):121-31.
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Saras A, Gisselmann G, Vogt-Eisele AK, Erlkamp KS, Kletke O, Pusch H, Hatt H.
Histamine action on vertebrate GABAA receptors: direct channel gating and potentiation of GABA responses.
J Biol Chem. 2008 Apr 18;283(16):10470-5. Epub 2008 Feb 15.
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