Milestone Papers

Histamine Metabolism
- Ohtsu H, Watanabe T.
  New functions of histamine found in histidine decarboxylase gene knockout mice.
  Biochem Biophys Res Commun. 2003 Jun 6;305(3):443-7.
- Yatsunami K, Ohtsu H, Tsuchikawa M, Higuchi T, Ishibashi K, Shida A, Shima Y, Nakagawa S, Yamauchi K, Yamamoto M, et al.
  Structure of the L-histidine decarboxylase gene.
  J Biol Chem. 1994 Jan 14;269(2):1554-9.
- Taguchi Y, Watanabe T, Kubota H, Hayashi H, Wada H.
  Purification of histidine decarboxylase from the liver of fetal rats and its immunochemical and immunohistochemical characterization.
  J Biol Chem. 1984 Apr 25;259(8):5214-21.
- Horton JR, Sawada K, Nishibori M, Zhang X, Cheng X.
  Two polymorphic forms of human histamine methyltransferase: structural, thermal, and kinetic comparisons.
  Structure. 2001 Sep;9(9):837-49.
- Aksoy S, Raftogianis R, Weinshilboum R.
  Human histamine N-methyltransferase gene: structural characterization and chromosomal location.
  Biochem Biophys Res Commun. 1996 Feb 15;219(2):548-54.
- Takemura M, Tanaka T, Taguchi Y, Imamura I, Mizuguchi H, Kuroda M, Fukui H, Yamatodani A, Wada H.
  Histamine N-methyltransferase from rat kidney. Cloning, nucleotide sequence, and expression in Escherichia coli cells.
  J Biol Chem. 1992 Aug 5;267(22):15687-91.
- Schwelberger HG, Drasche A, Hütter E.
  Analysis of mammalian diamine oxidase genes.
  Inflamm Res. 2000 Apr;49 Suppl 1:S51-2.
- Schwelberger HG, Bodner E.
  Purification and characterization of diamine oxidase from porcine kidney and intestine.
  Biochim Biophys Acta. 1997 Jun 20;1340(1):152-64.
- Mondovì B, Rotilio G, Finazzi A, Scioscia-Santoro A.
  Purification of pig-kidney diamine oxidase and its identity with histaminase.
  Biochem J. 1964 May;91(2):408-15.
Histamine Receptors
- Ohki E, Suzuki M, Aoe T, Ikawa Y, Negishi E, Ueno K.
  Expression of histamine H4 receptor in synovial cells from rheumatoid arthritic patients.
  Biol Pharm Bull. 2007 Nov;30(11):2217-20.
- Bell JK, McQueen DS, Rees JL.
  Involvement of histamine H4 and H1 receptors in scratching induced by histamine receptor agonists in Balb C mice.
  Br J Pharmacol. 2004 May;142(2):374-80. Epub 2004 Apr 5.
- Gbahou F, Rouleau A, Morisset S, Parmentier R, Crochet S, Lin JS, Ligneau X, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM.
  Protean agonism at histamine H3 receptors in vitro and in vivo.
  Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):11086-91. Epub 2003 Sep 5.
- Jablonowski JA, Grice CA, Chai W, Dvorak CA, Venable JD, Kwok AK, Ly KS, Wei J, Baker SM, Desai PJ, Jiang W, Wilson SJ, Thurmond RL, Karlsson L, Edwards JP, Lovenberg TW, Carruthers NI.
  The first potent and selective non-imidazole human histamine H4 receptor antagonists.
  J Med Chem. 2003 Sep 11;46(19):3957-60.
- Liu C, Ma X, Jiang X, Wilson SJ, Hofstra CL, Blevitt J, Pyati J, Li X, Chai W, Carruthers N, Lovenberg TW.
  Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow.
  Mol Pharmacol. 2001 Mar;59(3):420-6.
- Lovenberg TW, Roland BL, Wilson SJ, Jiang X, Pyati J, Huvar A, Jackson MR, Erlander MG.
  Cloning and functional expression of the human histamine H3 receptor.
  Mol Pharmacol. 1999 Jun;55(6):1101-7.
- Arrang JM, Garbarg M, Lancelot JC, Lecomte JM, Pollard H, Robba M, Schunack W, Schwartz JC.
  Highly potent and selective ligands for histamine H3-receptors.
  Nature. 1987 May 14-20;327(6118):117-23.
Histamine and Mast Cells
- Bischoff SC.
  Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data.
  Nat Rev Immunol. 2007 Feb;7(2):93-104.
- Theoharides TC, Papaliodis D, Tagen M, Konstantinidou A, Kempuraj D, Clemons A.
  Chronic fatigue syndrome, mast cells, and tricyclic antidepressants.
  J Clin Psychopharmacol. 2005 Dec;25(6):515-20. No abstract available.
- Marone G, Triggiani M, Genovese A, Paulis AD.
  Role of human mast cells and basophils in bronchial asthma.
  Adv Immunol. 2005;88:97-160.
- Marone G, Triggiani M, de Paulis A.
  Mast cells and basophils: friends as well as foes in bronchial asthma?
  Trends Immunol. 2005 Jan;26(1):25-31. Review.
- West GB.
  Histamine, mast cells and basophils.
  Chem Immunol. 1990;49:121-41. No abstract available.
- West GB.
  Plenary lecture. 'Mast cells revisited'.
  Agents Actions. 1986 Apr;18(1-2):5-18. No abstract available.
- Pearce FL, Ali H, Barrett KE, Befus AD, Bienenstock J, Brostoff J, Ennis M, Flint KC, Hudspith B, Johnson NM, et al.
  Functional characteristics of mucosal and connective tissue mast cells of man, the rat and other animals.
  Int Arch Allergy Appl Immunol. 1985;77(1-2):274-6.
- Barrett KE, Ennis M, Pearce FL.
  Mast cells isolated from guinea-pig lung: characterization and studies on histamine secretion.
  Agents Actions. 1983 Apr;13(2-3):122-6.
- Ennis M.
  Histamine release from human pulmonary mast cells.
  Agents Actions. 1982 Apr;12(1-2):60-3.
- Ennis M, Truneh A, White JR, Pearce FL.
  Inhibition of histamine secretion from mast cells.
  Nature. 1981 Jan 15;289(5794):186-7.
- Ennis M, Pearce FL.
  Differential reactivity of isolated mast cells from the rat and guinea pig.
  Eur J Pharmacol. 1980 Sep 5;66(4):339-45.
- Pearce FL, Ennis M.
  Isolation and some properties of mast cells from the mesentery of the rat and guinea pig.
  Agents Actions. 1980 Apr;10(1 Pt 2):124-31. No abstract available.
- Riley JF, West GB.
  The presence of histamine in tissue mast cells.
  J Physiol. 1953 Jun 29;120(4):528-37. No abstract available.
Histamine and Basophils
- Marone G, Triggiani M, Genovese A, Paulis AD.
  Role of human mast cells and basophils in bronchial asthma.
  Adv Immunol. 2005;88:97-160.
- Marone G, Triggiani M, de Paulis A.
  Mast cells and basophils: friends as well as foes in bronchial asthma?
  Trends Immunol. 2005 Jan;26(1):25-31. Review.
- West GB.
  Histamine, mast cells and basophils.
  Chem Immunol. 1990;49:121-41. No abstract available.
Histamine Release
- Barrett KE, Ennis M, Pearce FL.
  Mast cells isolated from guinea-pig lung: characterization and studies on histamine secretion.
  Agents Actions. 1983 Apr;13(2-3):122-6.
- Ennis M.
  Histamine release from human pulmonary mast cells.
  Agents Actions. 1982 Apr;12(1-2):60-3.
- Ennis M, Truneh A, White JR, Pearce FL.
  Inhibition of histamine secretion from mast cells.
  Nature. 1981 Jan 15;289(5794):186-7.
- Ennis M, Pearce FL.
  Differential reactivity of isolated mast cells from the rat and guinea pig.
  Eur J Pharmacol. 1980 Sep 5;66(4):339-45.
- Pearce FL, Ennis M.
  Isolation and some properties of mast cells from the mesentery of the rat and guinea pig.
  Agents Actions. 1980 Apr;10(1 Pt 2):124-31. No abstract available.
Histamine and Immune Response
- Horr B, Borck H, Thurmond R, Grösch S, Diel F.
  STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes.
  Int Immunopharmacol. 2006 Oct;6(10):1577-85.
- Akdis CA, Simons FE.
  Histamine receptors are hot in immunopharmacology.
  Eur J Pharmacol. 2006 Mar 8;533(1-3):69-76. Epub 2006 Jan 31. Review.
- Falus A, Meretey K.
  Histamine: an early messenger in inflammatory and immune reactions.
  Immunol Today. 1992 May;13(5):154-6. Review.
Histamine and Immunogenomics
- Fulop AK, Foldes A, Buzas E, Hegyi K, Miklos IH, Romics L, Kleiber M, Nagy A, Falus A, Kovacs KJ.
  Hyperleptinemia, visceral adiposity, and decreased glucose tolerance in mice with a targeted disruption of the histidine decarboxylase gene.
  Endocrinology. 2003 Oct;144(10):4306-14. Epub 2003 Jun 26.
- Fitzpatrick LA, Buzas E, Gagne TJ, Nagy A, Horvath C, Ferencz V, Mester A, Kari B, Ruan M, Falus A, Barsony J.
  Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss.
  Proc Natl Acad Sci U S A. 2003 May 13;100(10):6027-32. Epub 2003 Apr 25.
Histamine and Neurophysiology
- Breunig E, Michel K, Zeller F, Seidl S, Weyhern CW, Schemann M.
  Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors.
  J Physiol. 2007 Sep 1;583(Pt 2):731-42. Epub 2007 Jul 12.
- Morisset S, Rouleau A, Ligneau X, Gbahou F, Tardivel-Lacombe J, Stark H, Schunack W, Ganellin CR, Schwartz JC, Arrang JM.
  High constitutive activity of native H3 receptors regulates histamine neurons in brain.
  Nature. 2000 Dec 14;408(6814):860-4.
- Vorobjev VS, Sharonova IN, Walsh IB, Haas HL.
  Histamine potentiates N-methyl-D-aspartate responses in acutely isolated hippocampal neurons.
  Neuron. 1993 Nov;11(5):837-44.
- Haas HL, Konnerth A.
  Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells.
  Nature. 1983 Mar 31-Apr 6;302(5907):432-4.
Histamine and Brain Neurotransmitter Systems
- Sergeeva OA, Andreeva N, Garret M, Scherer A, Haas HL.
  Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
  J Neurosci. 2005 Jan 5;25(1):88-95.
- Haas H, Panula P.
  The role of histamine and the tuberomamillary nucleus in the nervous system.
  Nat Rev Neurosci. 2003 Feb;4(2):121-30. Review. No abstract available.
Histamine and Gastrointestinal Tract
- Varga C, Horvath K, Berko A, Thurmond RL, Dunford PJ, Whittle BJ.
  Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.
  Eur J Pharmacol. 2005 Oct 17;522(1-3):130-8. Epub 2005 Oct 6.
- Sander LE, Lorentz A, Sellge G, Coëffier M, Neipp M, Veres T, Frieling T, Meier PN, Manns MP, Bischoff SC.
  Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract.
  Gut. 2006 Apr;55(4):498-504. Epub 2005 Nov 18.
Histamine and Tumour Growth
- Pos Z, Safrany G, Muller K, Toth S, Falus A, Hegyesi H.
  Phenotypic profiling of engineered mouse melanomas with manipulated histamine production identifies histamine H2 receptor and rho-C as histamine-regulated melanoma progression markers.
  Cancer Res. 2005 May 15;65(10):4458-66.
- Falus A, Hegyesi H, Lazar-Molnar E, Pos Z, Laszlo V, Darvas Z.
  Paracrine and autocrine interactions in melanoma: histamine is a relevant player in local regulation.
  Trends Immunol. 2001 Dec;22(12):648-52. No abstract available.
Histamine and Disease
- Ligneau X, Landais L, Perrin D, Piriou J, Uguen M, Denis E, Robert P, Parmentier R, Anaclet C, Lin JS, Burban A, Arrang JM, Schwartz JC.
  Brain histamine and schizophrenia: potential therapeutic applications of H3-receptor inverse agonists studied with BF2.649.
  Biochem Pharmacol. 2007 Apr 15;73(8):1215-24. Epub 2007 Jan 21.
- Parmentier R, Anaclet C, Guhennec C, Brousseau E, Bricout D, Giboulot T, Bozyczko-Coyne D, Spiegel K, Ohtsu H, Williams M, Lin JS.
  The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders.
  Biochem Pharmacol. 2007 Apr 15;73(8):1157-71. Epub 2007 Jan 7.
- Passani MB, Lin JS, Hancock A, Crochet S, Blandina P.
  The histamine H3 receptor as a novel therapeutic target for cognitive and sleep disorders.
  Trends Pharmacol Sci. 2004 Dec;25(12):618-25. Review.
- Ikawa Y, Suzuki M, Shiono S, Ohki E, Moriya H, Negishi E, Ueno K.
  Histamine H4 receptor expression in human synovial cells obtained from patients suffering from rheumatoid arthritis.
  Biol Pharm Bull. 2005 Oct;28(10):2016-8.
- Celik I, Nies C, Lorenz W, Sitter H, Stinner B, Krack W, Krackrugge D, Kromer JH, Rothmund M.
  Influence of histamine H1+H2 receptor antagonists on abdominal infections following minimally invasive versus conventional surgery: studies in large samples of rats following the new concept of clinic modelling randomised trials (CMRT).
  Inflamm Res. 1999 Apr;48 Suppl 1:S51-2. No abstract available.
- Lorenz W, Duda D, Dick W, Sitter H, Doenicke A, Black A, Weber D, Menke H, Stinner B, Junginger T, et al.
  Incidence and clinical importance of perioperative histamine release: randomised study of volume loading and antihistamines after induction of anaesthesia. Trial Group Mainz/Marburg.
  Lancet. 1994 Apr 16;343(8903):933-40.
- Lorenz W.
  Histamine and antihistamines in anaesthesia and surgery: from experimental pharmacology to clinical decision making.
  Agents Actions Suppl. 1992;36:34-56. Review.

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